LIANA: a LIgand-receptor ANalysis frAmework
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Updated
Aug 7, 2024 - R
LIANA: a LIgand-receptor ANalysis frAmework
A comprehensive computational pipeline that bridges single-cell genomics and cheminformatics to accelerate Alzheimer's Disease research. This project integrates advanced bioinformatics and machine learning to create a seamless workflow from raw single-cell RNA sequencing data to predictive drug discovery models.
Generate Sankey plots from merged CellChat objects
Customize your specific organism cellchatdb
This project analyzes how differences in the mathematical frameworks of CellChat and CellPhoneDB affect cell–cell communication inference from single-cell RNA-seq data in diet-induced liver disease.
Modular single-cell transcriptomics pipelines for Alzheimer’s disease, integrating R and Python workflows.
Retinal ganglion cells regeneration in 2 days post optic nerve crush retina | Lydia Tai | Dong Feng Chen Lab collaboration | Schepens Eye Research Institute, Mass General Hospital, Harvard Medical School
Single-cell RNA-seq analysis of human bone marrow and CD34+ cells using Seurat, SingleR, DoubletFinder and CellChat.
Spatial transcriptomics analysis of macrophages in chronic kidney disease (CKD): cell2location deconvolution, CellChat cell-cell communication, differential expression and co-expression analysis (Python/R).
Spatial transcriptomics analysis of paired baseline and on-treatment samples using Seurat and CellChat
Code-only downstream scRNA-seq workflows for PBMC and colorectal cancer analyses, with reproducible entry points and expected output structure.
A geometry-aware framework for prioritizing biologically meaningful ligand–receptor interactions in spatial transcriptomics.
Reproducible R analysis code for fibroblast FLRT2–UNC5C signalling in human obese HFpEF (single-nucleus + orthogonal-bulk, CellChat)
Growth Hormone effect on Cartilage Growth Plate; Light-Sheet Microscopy; Pseudocoloring | Projects I started and still working on in Andrei Chagin Lab | Karolinska Institutet
Socs3/Spp1 Project on Microglia in OIR | Ye Sun Lab Collaboration Project | Boston Children's Hospital
English Windows desktop application for downstream single-cell RNA-seq analysis with CellChat, cell-cycle, and Monocle 3 pseudotime workflows.
End-to-end single-cell RNA-seq analyses on public datasets — 10 reproducible projects in Scanpy & Seurat covering integration, trajectory inference, cell-cell communication, and method benchmarks.
可视化2026718V1:离线科研图形决策、Scheme/Recipe 检索、R/Python 适配渲染与科学视觉复核
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